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The bi-annual worldwide survey was conducted online between January and March 2015. More than 12,000 people participated, making this the This section explores the public’s literacy and perceptions of clinical research. Clinical research topics in this part of the survey include knowledge and understanding, general willingness to participate, level of trust in sources of information, and more. This section looks at what motivates people to participate in clinical research and what deters them from participating. Results are presented by subgroup differences such as region, race and ethnicity, income and education level, age, and severity of disease. This section focuses on the experiences of study volunteers. Among the 12,009 survey respondents, about 3,122 had participated in a clinical trial. Here, we compare subgroups such as geography, age, and disease severity for different aspects of their study experiences. This section explores the public’s literacy and perceptions of clinical research. This section looks at what motivates people to participate in clinical research and what deters them from participating. This section focuses on the experiences of study volunteers. Among the 12,009 survey respondents, about 3,122 had participated in a clinical a global study on public and patient perceptions of clinical research. The aim of this study was to resume and establish routine global as*essment of perceptions, motivations, and experiences with clinical research participation. The insights from the 2015 global study help to monitor trends and identify opportunities to better inform and engage the public and patients as stakeholders and partners in the clinical research enterprise. The reports were produced based on an online international survey CISCRP conducted between January and March 2015. The survey instrument was based in part on questions posed in past surveys. CISCRP received input and support from pharmaceutical, biotechnology, and contract